Shim-pack GIS CN is capable of either normal phase or reversed phase analysis. Cyanopropryl groups bonded to silica gel with high density increases the difference recognition of hydrophilicity and the stability. Due to no end-capping, it is capable of analysis utilizing cyano group characteristics. In reversed phase mode, separation can be achieved for those compounds that could not be separated on straight-chain-alkyl columns, such as C18 or C8 bonded phases. When using the column for reversed phase mode, fully equilibrate the column before use.